The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Aug. 24, 2020
Fundació Privada Institutció Catalana DE Recerca I Estudis Avançats (Icrea), Barcelona, ES;
Fundació Privada Institut D'investigatió Oncológica DE Vall Hebron (Vhio), Barcelona, ES;
Fundacio Privada Institut DE Recerca Hospital Universitari Vall Hebron (Ir-huvh), Barcelona, ES;
Joan Seoane Suarez, Barcelona, ES;
Silvia Penuelas Prieto, Barcelona, ES;
José Baselga Torres, Barcelona, ES;
Abstract
The invention is based on observing that LIF is capable of activating the self-renewal of tumor stem cells in cancer, in particular gliomas, which indicates that the inhibition of LIF, and generally of IL-6 type cytokines, can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation. The invention also relates to a method for the identification of compounds capable of blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of subjects suffering from said tumors.