The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Jan. 11, 2021
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health, Bethesda, MD (US);
Inventors:
Linkun An, Guangzhou, CN;
Christophe Marchand, Silver Spring, MD (US);
Yves Pommier, Bethesda, MD (US);
Assignee:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/343 (2006.01); A61K 31/122 (2006.01); A61K 31/136 (2006.01); A61K 31/194 (2006.01); A61K 31/47 (2006.01); A61K 31/473 (2006.01); A61K 31/4741 (2006.01); A61K 31/4745 (2006.01); A61K 31/475 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61K 31/5377 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 45/06 (2006.01); C07D 221/08 (2006.01); C07D 307/92 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/122 (2013.01); A61K 31/136 (2013.01); A61K 31/194 (2013.01); A61K 31/343 (2013.01); A61K 31/47 (2013.01); A61K 31/473 (2013.01); A61K 31/4741 (2013.01); A61K 31/4745 (2013.01); A61K 31/475 (2013.01); A61K 31/496 (2013.01); A61K 31/498 (2013.01); A61K 31/5377 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 45/06 (2013.01); C07D 221/08 (2013.01); C07D 307/92 (2013.01); C07D 471/04 (2013.01); C07D 491/04 (2013.01); C07D 498/04 (2013.01);
Abstract
Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed The variables X, X, and Rare disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula I are also disclosed.