The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Dec. 29, 2017
Applicant:
Vaxcyte, Inc., San Carlos, CA (US);
Inventors:
Jeffery Fairman, Mountain View, CA (US);
Jon H. Heinrichs, Doylestown, PA (US);
Wei Chan, San Francisco, CA (US);
Assignee:
Vaxcyte, Inc., San Carlos, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 39/09 (2006.01); A61K 47/64 (2017.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 37/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/385 (2013.01); A61K 39/092 (2013.01); A61K 47/6415 (2017.08); A61K 47/646 (2017.08); A61P 29/00 (2018.01); A61P 31/04 (2018.01); A61P 37/00 (2018.01); A61K 2039/575 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/627 (2013.01);
Abstract
Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.