The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Dec. 31, 2017
Hangzhou Dac Biotech Co., Ltd., Hangzhou, CN;
Robert Yongxin Zhao, Lexington, MA (US);
Qingliang Yang, Hangzhou, CN;
Yuanyuan Huang, Hangzhou, CN;
Linyao Zhao, Hangzhou, CN;
Shun Gai, Hangzhou, CN;
Hangbo Ye, Hangzhou, CN;
Jun Lei, Hangzhou, CN;
Yifang Xu, Hangzhou, CN;
Mingjun Cao, Hangzhou, CN;
Huihui Guo, Hangzhou, CN;
Junxiang Jia, Hangzhou, CN;
Qianqian Tong, Hangzhou, CN;
Wenjun Li, Hangzhou, CN;
Xiaomai Zhou, Hangzhou, CN;
Hongsheng Xie, Hangzhou, CN;
Lu Bai, Hangzhou, CN;
Xiang Cai, Hangzhou, CN;
Xiaotao Zhuo, Hangzhou, CN;
Xiuzheng Zhang, Hangzhou, CN;
Jun Zheng, Hangzhou, CN;
Hangzhou DAC Biotech Co., Ltd., Hangzhou, CN;
Abstract
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.