The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Mar. 24, 2016
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Brian B. Liau, Boston, MA (US);
Anoop P. Patel, Boston, MA (US);
Cem Sievers, Boston, MA (US);
Bradley E. Bernstein, Boston, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 31/44 (2006.01); A61K 31/506 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 31/44 (2013.01); A61K 31/506 (2013.01); A61K 31/55 (2013.01); A61K 31/5513 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 2300/00 (2013.01);
Abstract
The present invention provides compositions and methods for the treatment of drug-tolerant glioblastoma, and in particular glioblastoma stem cells. Specifically, the methods comprise contacting a glioblastoma stem cell with a platelet-derived growth factor receptor alpha inhibitor and one or more of a histone lysine demethylase inhibitor and a Notch inhibitor.