The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2024

Filed:

Feb. 28, 2019
Applicant:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Joshua C. Doverspike, Ann Arbor, MI (US);

James Phan, Lake Orion, MI (US);

Jianfeng Wu, Canton, MI (US);

Chuanwu Xi, Ann Arbor, MI (US);

Yu Qin, Ann Arbor, MI (US);

Mark E. Meyerhoff, Ann Arbor, MI (US);

Yang Zhou, Ann Arbor, MI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/04 (2006.01); A61K 31/198 (2006.01); A61K 33/30 (2006.01); A61K 38/06 (2006.01); A61K 47/06 (2006.01); B01J 23/72 (2006.01); B01J 31/02 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/04 (2013.01); A61K 31/198 (2013.01); A61K 33/30 (2013.01); A61K 38/063 (2013.01); A61K 47/06 (2013.01); B01J 23/72 (2013.01); B01J 31/0272 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01);
Abstract

A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.


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