The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2024
Filed:
Apr. 26, 2019
Tufts Medical Center, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Pedram Hamrah, Wellesley, MA (US);
Neslihan Dilruba Koseoglu, Boston, MA (US);
Andrew Beam, Boston, MA (US);
Tufts Medical Center, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer N programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention. The invention further provides a non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, perform a method for automatically determining the presence of at least one neuroma on a plurality of images of an ocular surface of a patient.