The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2024
Filed:
Oct. 31, 2017
Applicant:
Yu-feng HU, Taipei, TW;
Inventors:
Assignees:
TAIPEI VETERANS GENERAL HOSPITAL, Taipei, TW;
NATIONAL YANG MING CHIAO TUNG UNIVERSITY, Hsinchu, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/34 (2015.01); A61N 1/32 (2006.01); C12N 5/0735 (2010.01); C12N 5/077 (2010.01); A61N 1/37 (2006.01); C12N 5/071 (2010.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0606 (2013.01); A61N 1/326 (2013.01); C12N 5/0657 (2013.01); A61K 35/34 (2013.01); A61N 1/3702 (2013.01); C12N 5/0692 (2013.01); C12N 5/0696 (2013.01); C12N 2500/82 (2013.01); C12N 2501/10 (2013.01); C12N 2506/02 (2013.01); C12N 2510/00 (2013.01); C12N 2510/02 (2013.01); C12N 2533/52 (2013.01);
Abstract
Disclosed herein are methods and compositions for generating pacemaker cells from non-pacemaker cardiomyocytes. For example, the method includes the step of culturing the non-pacemaker cardiomyocytes with silk fibroin so that the silk fibroin induces the transformation of at least a portion thereof into pacemaker cells.