The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2024
Filed:
Jan. 11, 2018
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Vincent Christopher Luca, Menlo Park, CA (US);
Kenan Christopher Garcia, Menlo Park, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 38/00 (2006.01); C07K 14/54 (2006.01); C07K 14/55 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/5406 (2013.01); C07K 14/55 (2013.01); A61K 38/00 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2319/21 (2013.01); C07K 2319/81 (2013.01);
Abstract
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.