The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 28, 2024

Filed:

Apr. 28, 2021
Applicant:

Sage Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Albert Jean Robichaud, Boston, MA (US);

Gabriel Martinez Botella, Wayland, MA (US);

Boyd L. Harrison, Princeton Junction, NJ (US);

Francesco G. Salituro, Marlborough, MA (US);

Andrew Griffin, L'Ile Bizard, CA;

Maria Jesus Blanco-Pillado, Arlington, MA (US);

Assignee:

Sage Therapeutics, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/20 (2006.01); C07J 1/00 (2006.01); C07J 7/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); A61P 25/00 (2018.01); C07J 1/0029 (2013.01); C07J 7/002 (2013.01); C07J 7/003 (2013.01); C07J 7/006 (2013.01); C07J 41/005 (2013.01); C07J 41/0094 (2013.01);
Abstract

Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R, R, R, R, R, R, R, R, R, R, R, R, andare as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.


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