IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11993574 B1

PDFFull Text
Date of Patent:
May. 28, 2024

Filed:

Jun. 17, 2019

Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma

Applicant:

Reata Pharmaceuticals, Inc., Irving, TX (US);

Inventors:

Xin Jiang, Irving, TX (US);

Melean Visnick, Irving, TX (US);

Christopher F. Bender, Irving, TX (US);

Gary Bolton, Irving, TX (US);

Bradley Caprathe, Irving, TX (US);

Chitase Lee, Irving, TX (US);

Brian Kornberg, Irving, TX (US);

Patrick O'Brien, Irving, TX (US);

Martha R. Hotema, Irving, TX (US);

Assignee:

REATA PHARMACEUTICALS, INC, Irving, TX (US);

Attorney:

Parker Highlander PLLC

Primary Examiner:

Deepak R Rao

Int. Cl.
CPC ...
C07D 231/54 (2006.01); C07D 235/02 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 413/10 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 231/54 (2013.01); C07D 235/02 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01);
Abstract

Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.

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