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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11992560 B1

PDFFull Text
Date of Patent:
May. 28, 2024

Filed:

Jun. 14, 2018

Electrospun fibers for a local release of an anti-inflammatory drug and a promyelinating drug

Applicant:

Alma Mater Studiorum—università Di Bologna, Bologna, IT;

Inventors:

Laura Calza, Monterenzio, IT;

Luciana Giardino, Monterenzio, IT;

Maria Letizia Focarete, Bologna, IT;

Chiara Gualandi, Molinella, IT;

Maria-Laura Bolognesi, Bologna, IT;

Nadia Passerini, Bologna, IT;

Giampiero Pagliuca, Bologna, IT;

Teresa Gazzotti, Bologna, IT;

Elisa Zironi, Sasso Marconi, IT;

Assignee:

ALMA MATER STUDIORUM—UNIVERSITÀ DI BOLOGNA, Bologna, IT;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Jianfeng Song

Int. Cl.
CPC ...
A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 31/12 (2006.01); A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/197 (2006.01); A61K 31/198 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 31/407 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/4418 (2006.01); A61K 31/5415 (2006.01); A61K 31/5575 (2006.01); A61K 31/603 (2006.01); A61K 31/704 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 9/70 (2013.01); A61K 9/0024 (2013.01); A61K 31/12 (2013.01); A61K 31/19 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/197 (2013.01); A61K 31/198 (2013.01); A61K 31/40 (2013.01); A61K 31/405 (2013.01); A61K 31/407 (2013.01); A61K 31/42 (2013.01); A61K 31/421 (2013.01); A61K 31/4418 (2013.01); A61K 31/5415 (2013.01); A61K 31/5575 (2013.01); A61K 31/603 (2013.01); A61K 31/704 (2013.01); A61P 25/28 (2018.01);
Abstract

The present invention relates to electro spun fibers for a local release in the central nervous system of an anti-inflammatory and a promyelinating agent over a defined time-window, in order to limit secondary neurodegeneration triggered by the glutamate release and supported by on-going inflammation. The combined treatment aimed to reduce inflammation and improve remyelination in the very early stage of the pathology improving the chronic clinical outcome of the lesion. In particular the present invention relates to electrospun polymeric fibers, wherein said fibers are loaded with 3,3,5-Triiodo-L-thyronine (T3) and Ibuprofen.

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