The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 2024
Filed:
Dec. 09, 2022
Yantai Lannacheng Biotechnology Co., Ltd., Shandong, CN;
Xiaoyuan Chen, Shandong, CN;
Pengfei Xu, Shandong, CN;
Xiaoming Wu, Shandong, CN;
Zhide Guo, Shandong, CN;
Qingbao Yang, Shandong, CN;
Xuejun Wen, Shandong, CN;
YANTAI LANNACHENG BIOTECHNOLOGY CO., LTD., Shandong, CN;
Abstract
The present disclosure relates to the fields of nuclear medicine and molecular imaging, and specifically relates to a dual-targeting compound and a preparation method and application thereof. The dual-targeting compound has the following structure shown in Formula (I). The present disclosure also provides a dual-targeting compound capable of being labeled with a radionuclide, and the compound has the following structure shown in Formula (I-1) or Formula (1-2). The dual-targeting compound of the present disclosure has high affinity for an FAP target and an integrin αβtarget, can realize synergistic targeting of the FAP target and the integrin αβtarget in tumors, and has high uptake in tumors and long retention time in tumors. The present disclosure also provides a radionuclide labeled dual-targeting compound based on the dual-targeting compound, and a preparation method and application thereof in preparation of medicines for diagnosis or therapy of diseases characterized by overexpression of FAP and/or integrin αβ.