The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2024
Filed:
Jun. 16, 2022
Zhejiang University, Hangzhou, CN;
Ruiliang Bai, Hangzhou, CN;
Yinhang Jia, Hangzhou, CN;
Yingchao Liu, Hangzhou, CN;
Guangxu Han, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
The invention discloses a method for measuring the intracellular water transmembrane efflux rate (k): setting magnetic resonance imaging parameters and measuring the noise level during scanning. Optimizing the flip angle and resetting it through Monte Carlo simulation. Scanning quantitative T1 imaging. Scanning dynamic-contrast-enhanced magnetic resonance imaging and injecting contrast agent. The full shutter speed model (SSM) is used to analyze every voxel in the tumor area and obtain the kof them. This method significantly improves the accuracy of k. The invention discloses the measuring method, system and application of kas a magnetic resonance imaging biomarker of glioma, which is not for disease diagnosis, to evaluate the expression level of AQP4. The invention discloses the application of kas a magnetic resonance imaging marker of glioma in the preparation of a product for predicting the sensitivity of glioma radiotherapy and chemotherapy. Through the above methods, systems and applications, the non-invasive and quantitative measurement and imaging of AQP4 expression level in glioma have been realized.