The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2024
Filed:
Aug. 09, 2021
Applicant:
Omniox, Inc., San Carlos, CA (US);
Inventors:
Gregory Kapp, San Francisco, CA (US);
Laura Serwer, Brisbane, CA (US);
Natacha Le Moan, San Francisco, CA (US);
Stephen P. L. Cary, San Mateo, CA (US);
Assignee:
OMNIOX, INC., San Carlos, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); A61K 38/16 (2006.01); A61K 38/41 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); C07K 14/795 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/795 (2013.01); A61K 38/164 (2013.01); A61K 38/41 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); G01N 33/53 (2013.01); G01N 33/57407 (2013.01); A61K 38/00 (2013.01); A61N 2005/1098 (2013.01); C07K 2319/21 (2013.01); G01N 2800/52 (2013.01); Y02A 50/30 (2018.01);
Abstract
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.