The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
Feb. 20, 2019
Case Western Reserve University, Cleveland, OH (US);
Anant Madabhushi, Shaker Heights, OH (US);
Nathaniel Braman, Cleveland, OH (US);
Kavya Ravichandran, Westlake, OH (US);
Andrew Janowczyk, East Meadow, NY (US);
Case Western Reserve University, Cleveland, OH (US);
Abstract
Embodiments predict response to neoadjuvant chemotherapy (NAC) in breast cancer (BCa) from pre-treatment dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Embodiments compute, using a machine learning (ML) classifier, a first probability of response based on a set of radiomic features extracted from a tumoral region represented in a pre-treatment DCE-MRI image of a region of tissue (ROT) demonstrating BCa; extract patches from the tumoral region; provide the patches to a convolutional neural network (CNN); receive, from the CNN, a pixel-level localized patch probability of response; compute a second probability of response based on the pixel-level localized patch probability; compute a combined ML probability from the first and second probabilities; compute a final probability of response based on the combined ML probability and clinical information associated with the ROT; classify the ROT as a responder or non-responder based on the final probability of response; and display the classification.