The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
May. 12, 2021
Applicant:
Philip Morris Products S.a., Neuchatel, CH;
Inventors:
David Bovard, Erlach, CH;
Karsta Luettich, Hauterive, CH;
Assignee:
Philip Morris Products S.A., Neuchatel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12M 3/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0671 (2013.01); C12M 21/08 (2013.01); C12N 5/0688 (2013.01); G01N 33/5014 (2013.01); G01N 33/5082 (2013.01); C12N 2500/00 (2013.01); C12N 2502/14 (2013.01); C12N 2502/27 (2013.01);
Abstract
There is described an isolated 3-dimensional liver spheroid wherein said spheroid has: increased ATP content as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; the same or increased activity of cytochrome P450 1A1 and cytochrome P450 1B1 as compared to a 3-dimensional liver spheroid cultured in Complete William's E medium alone; and increased albumin secretion as compared to a 3-dimensional liver spheroid cultured in William's E medium alone.