The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
Aug. 04, 2020
Applicants:
Omeros Corporation, Seattle, WA (US);
University of Leicester, Leicestershire, GB;
Inventors:
Gregory A. Demopulos, Mercer Island, WA (US);
Thomas A. Dudler, Bellevue, WA (US);
Hans-Wilhelm Schwaeble, Cambridge, GB;
Assignees:
OMEROS CORPORATION, Seattle, WA (US);
UNIVERSITY OF LEICESTER, Leicester, GB;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61P 7/02 (2006.01); A61P 37/02 (2006.01); C07K 16/40 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61P 7/02 (2018.01); A61P 37/02 (2018.01); C12Y 304/21104 (2013.01); A61K 2039/505 (2013.01); C07K 2317/20 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from TMA associated with hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.