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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11981744 B1

PDFFull Text
Date of Patent:
May. 14, 2024

Filed:

Dec. 19, 2022

Chimeric polypeptide assembly and methods of making and using the same

Applicant:

Amunix Pharmaceuticals, Inc., Mountain View, CA (US);

Inventors:

Volker Schellenberger, Palo Alto, CA (US);

Fan Yang, San Jose, CA (US);

Desiree Thayer, Burlingame, CA (US);

Bee-Cheng Sim, Mountain View, CA (US);

Chia-Wei Wang, Santa Clara, CA (US);

Assignee:

AMUNIX PHARMACEUTICALS, INC., Mountain View, CA (US);

Attorneys:

LATHROP GPM LLP

James H. Velema, Esq.

Michael J. Spellberg, Esq.

Primary Examiner:

Brad Duffy

Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61P 35/00 (2006.01); C07K 14/00 (2006.01); C07K 16/28 (2006.01); C12N 5/09 (2010.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61P 35/00 (2018.01); C07K 14/00 (2013.01); C07K 16/2809 (2013.01); C12N 5/0693 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/572 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/60 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/90 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/01 (2013.01); C07K 2319/035 (2013.01); C07K 2319/21 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/50 (2013.01); C12N 2523/00 (2013.01);
Abstract

The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

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