The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
Feb. 05, 2019
Applicant:
Ibex Biosciences, Inc., Cumberland, MD (US);
Inventors:
Norman Zhennan Lai, N. Potomac, MD (US);
Michael Joseph Karlin, Bethesda, MD (US);
Alberto Murat Croci, Washington, DC (US);
Vidal Felix de la Cruz, Jr., Phoenixville, PA (US);
Yuebin Tan, Cumberland, MD (US);
Assignee:
Ibex Biosciences, Inc., Cumberland, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61P 35/04 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61P 35/04 (2018.01); C12N 15/86 (2013.01);
Abstract
The present disclosure provides compositions and methods of using gene therapy to decrease cell migration and metastasis and reduce tumor mass or burden. The methods disclosed herein employ plasmids, vectors, and non-viral vectors that contain PCBP1 and/or PCBP1 mutants which inhibit the expression of cancer biomarkers and decrease cell migration or tumor size.