The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
May. 31, 2022
Applicant:
Novelwise Pharmaceutical Corporation, Taipei, TW;
Inventors:
Chung-Yang Huang, Taipei, TW;
Chia-Chung Hou, Taipei, TW;
Assignee:
NOVELWISE PHARMACEUTICAL CORPORATION, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/085 (2006.01); A61K 31/495 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/085 (2013.01); A61K 31/495 (2013.01); A61P 35/00 (2018.01);
Abstract
The present invention provides a combination and method for treating a Temozolomide (TMZ)-resistant cancer patient, which comprises a combination of TMZ and an isoform-selective HDAC8 inhibitor, such as BMX at an effective relative ratio to overcome TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the β-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition.
Huang, Chung-Yang. (2024). Composition and method for treating a drug-resistant cancer (U.S. Patent No. 11980594). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11980594
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile