The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Oct. 20, 2020
Applicant:
Boise State University, Boise, ID (US);
Inventors:
Assignee:
Boise State University, Boise, ID (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/08 (2006.01); C12N 15/10 (2006.01); C12N 15/115 (2010.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
C40B 40/08 (2013.01); C12N 15/1048 (2013.01); C12N 15/115 (2013.01); G01N 21/6428 (2013.01); C12N 2310/16 (2013.01); C12N 2320/10 (2013.01); C12N 2320/11 (2013.01); C12N 2320/13 (2013.01); G01N 2021/6439 (2013.01);
Abstract
The present disclosure relates to oligonucleotide biosensors that bind to a fluorophore through a reporter domain and to one or more target ligand(s) through one or more target domain(s), which is connected to the reporter domain through one or more linker domain(s). The binding of the target ligand to the target domain affects the fluorescence of the fluorophore when excited by the appropriate wavelength of energy, either by causing dimming or allosteric fluorescence. Methods of selecting biosensors and their use to detect target ligands are also described.