The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Oct. 10, 2016
Applicant:
Université Du Luxembourg, Esch-sur-Alzette, LU;
Inventors:
Assignee:
UNIVERSITÉ DU LUXEMBOURG, Esch-sur-Alzette, LU;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0793 (2010.01); C12N 5/079 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); C12N 5/0622 (2013.01); G01N 33/5058 (2013.01); G01N 33/5088 (2013.01); C12N 2500/38 (2013.01); C12N 2501/01 (2013.01); C12N 2501/115 (2013.01); C12N 2501/119 (2013.01); C12N 2501/13 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/41 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2506/11 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/90 (2013.01);
Abstract
The present invention provides means and methods for the generation of midbrain organoids which are useful for studying neurodevelopmental and neurodegenerative diseases. Neuroepithelial stem cells serve as a starting population for the generation of midbrain organoids by contacting them with differentiation medium under agitating conditions in three-dimensional cell culture comprising a matrix.