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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11976292 B1

PDFFull Text
Date of Patent:
May. 07, 2024

Filed:

Dec. 12, 2016

Non-integrating viral delivery system and methods related thereto

Applicant:

American Gene Technologies International Inc., Rockville, MD (US);

Inventors:

Charles David Pauza, Rockville, MD (US);

Tyler Lahusen, Rockville, MD (US);

Assignee:

American Gene Technologies International Inc., Rockville, MD (US);

Attorney:

DLA Piper LLP (US)

Primary Examiner:

Quang Nguyen

Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 35/76 (2015.01); A61K 38/18 (2006.01); A61K 48/00 (2006.01); A61P 31/18 (2006.01); C07K 14/435 (2006.01); C07K 14/475 (2006.01); C07K 14/49 (2006.01); C07K 14/51 (2006.01); C07K 16/10 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12N 15/113 (2010.01); C12N 15/63 (2006.01); A61K 9/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/76 (2013.01); A61K 38/1866 (2013.01); A61K 48/00 (2013.01); A61K 48/005 (2013.01); A61P 31/18 (2018.01); C07K 14/43504 (2013.01); C07K 14/475 (2013.01); C07K 14/49 (2013.01); C07K 14/51 (2013.01); C07K 16/10 (2013.01); C07K 16/1045 (2013.01); C07K 16/22 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); C12N 15/113 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5256 (2013.01); C07K 2317/14 (2013.01); C12N 2310/141 (2013.01); C12N 2710/20022 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2830/60 (2013.01);
Abstract

A non-integrating viral delivery system is disclosed. The system includes a viral carrier, wherein the viral carrier contains a defective integrase gene; a heterologous viral episomal origin of replication; a sequence encoding at least one initiator protein specific for the heterologous viral episomal origin of replication, wherein expression of the sequence encoding the at least one initiator protein specific for the heterologous viral episomal origin of DNA replication is inducible; and at least one gene, gene product, shRNA, siRNA, miRNA, or other RNA of interest.

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