The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Dec. 08, 2022
Applicant:
The National Institute for Biotechnology IN the Negev Ltd., Beer Sheva, IL;
Inventors:
Assignee:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer Sheva, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 47/64 (2017.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 47/64 (2017.08); A61K 47/6455 (2017.08); A61P 35/00 (2018.01); C07K 14/4747 (2013.01); C12N 2310/14 (2013.01); C12N 2310/321 (2013.01);
Abstract
The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.