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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11976277 B1

PDFFull Text
Date of Patent:
May. 07, 2024

Filed:

Feb. 03, 2023

Particle delivery systems

Applicant:

Scribe Therapeutics Inc., Alameda, CA (US);

Inventors:

Jason Fernandes, Redwood City, CA (US);

Sean Higgins, Alameda, CA (US);

Isabel Colin, Oakland, CA (US);

Hannah Spinner, Boston, MA (US);

Matthew Gardner, Berkeley, CA (US);

Trent Gomberg, San Diego, CA (US);

Gayathri Vijayakumar, Oakland, CA (US);

Sarah Denny, San Francisco, CA (US);

Brett T. Staahl, Tiburon, CA (US);

Maroof Adil, Davis, CA (US);

Benjamin Oakes, El Cerrito, CA (US);

Angus Sidore, Oakland, CA (US);

Suraj Makhija, San Francisco, CA (US);

Assignee:

Scribe Therapeutics Inc., Alameda, CA (US);

Attorney:

Cooley LLP

Primary Examiner:

J E Angell

Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); C07K 14/005 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); A61K 9/0019 (2013.01); A61K 9/5052 (2013.01); C07K 14/005 (2013.01); C12N 9/22 (2013.01); C12N 2310/16 (2013.01); C12N 2310/20 (2017.05); C12N 2310/3519 (2013.01); C12N 2320/32 (2013.01);
Abstract

Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modification of nucleic acids in target cells. Also provided are methods of making and using such XDP to modify the nucleic acids in such cells.

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Fernandes, Jason. (2024). Particle delivery systems (U.S. Patent No. 11976277). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11976277

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