The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Apr. 04, 2022
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Assignee:
Genzyme Coporation, Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/22 (2006.01); C07K 16/46 (2006.01); C12N 15/11 (2006.01); C12N 15/62 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C07K 16/00 (2013.01); C07K 16/46 (2013.01); C12N 15/11 (2013.01); C12N 15/62 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/53 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/626 (2013.01); C07K 2317/64 (2013.01); C07K 2317/70 (2013.01); C07K 2317/72 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/23 (2013.01); C07K 2319/73 (2013.01);
Abstract
An scFv-Fc dimer binds and neutralizes TGFβ1 selectively and with high affinity and avidity. The scFv region may comprise the same VH and VL domains or CDR regions as metelimumab. The unique combination of their smaller size, high selectivity, potency against TGFβ1, and long in vivo half-life makes the scFv-Fc dimers ideal candidates for therapeutic applications.