The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2024
Filed:
Nov. 12, 2018
Ohio State Innovation Foundation, Columbus, OH (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Peixuan Guo, Dublin, OH (US);
Mario Vieweger, Columbus, OH (US);
Xin Li, Dublin, OH (US);
Sijin Guo, Dublin, OH (US);
Hongran Yin, Dublin, OH (US);
Xijun Piao, San Diego, CA (US);
Yi Shu, Columbus, OH (US);
Dan Shu, Columbus, OH (US);
Mehdi Rajabi, Columbus, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Abstract
Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.