The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 07, 2024

Filed:

Nov. 10, 2023
Applicant:

Xiamen Lp Pharmaceutical Co., Ltd., Xiamen, CN;

Inventors:

Avinash Singh, Xiamen, CN;

Rongbin Ling, Xiamen, CN;

Liyuan Chen, Xiamen, CN;

Fuxiang Lin, Xiamen, CN;

Haijian Zhu, Xiamen, CN;

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 9/00 (2006.01); A61K 47/06 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/28 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61K 47/40 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4985 (2013.01); A61K 9/006 (2013.01); A61K 47/06 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/28 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61K 47/40 (2013.01);
Abstract

The present invention provides an oral transmucosal film for delivering tadalafil through the buccal mucosa or sublingual mucosa. The film is a single layer structure containing amorphous tadalafil, one or more solubilizers, one or more penetration enhancers, and one or more adhesives to deliver the drug through a transmucosal route. Comparing with an oral tadalafil tablet, the present oral transmucosal film provides improved absorption rate and Tmax. The oral transmucosal film comprises 5%-60% by weight of amorphous tadalafil, 25-96% by weight of a film-forming material, 1-20% by weight of a solubilizer, 0.5-10% by weight of a penetration enhancer, and 1-15% by weight of an adhesive.


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