The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2024

Filed:

Oct. 13, 2016
Applicants:

Duke University, Durham, NC (US);

North Carolina State University, Raleigh, NC (US);

Inventors:

Charles A. Gersbach, Durham, NC (US);

Adrian Pickar Oliver, Durham, NC (US);

Chase Beisel, Raleigh, NC (US);

Assignees:

Duke University, Durham, NC (US);

North Carolina State University, Raleigh, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 9/22 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C07K 2319/00 (2013.01); C07K 2319/09 (2013.01); C07K 2319/21 (2013.01); C07K 2319/41 (2013.01); C07K 2319/43 (2013.01); C07K 2319/80 (2013.01); C12N 2310/20 (2017.05); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2800/22 (2013.01); C12N 2830/001 (2013.01);
Abstract

Disclosed herein are Type I Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) system related compositions and methods of using said Type I CRISPR/Cas system related compositions for altering gene expression and genome engineering. The invention relates to compositions comprising Type I CRISPR-Cas polypeptides and CRISPR array nucleic acids designed for genome modification in eukaryotic cells and for targeted killing of eukaryotic cells.


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