The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2024
Filed:
Mar. 19, 2019
Sanofi Pasteur Inc., Swiftwater, PA (US);
Patrick Farrell, Holland Landing, CA;
Bo Zhi Sun, Waterdown, CA;
Fabien Barbirato, Brignais, FR;
Javier de Jesus Menendez Diaz, Pickering, CA;
Andrew Chiappetta, Vaughan, CA;
SANOFI PASTEUR INC., Swiftwater, PA (US);
Abstract
The present disclosure is directed to a method for cultivating aspecies, comprising: cultivating aspecies under aerobic conditions in a liquid culture medium; and maintaining a pH of the liquid culture medium by using a strong acid, such as nitric acid, or using a first and second acid, wherein the first acid is an inorganic acid that dissociates essentially completely in water, such as nitric acid, hydrochloric acid or sulfuric acid, and wherein the second acid is an inorganic acid having an acid dissociation constant (pKa) of greater than 1, such as phosphoric acid. Methods for increasing the yield offimbrial agglutinogen 2 and fimbrial agglutinogen 3 (FIM2/3) in a supernatant fraction from aculture are also provided.