The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2024

Filed:

Mar. 30, 2017
Applicant:

Emulate, Inc., Boston, MA (US);

Inventors:

Geraldine A. Hamilton, Boston, MA (US);

Norman Wen, West Roxbury, MA (US);

Catherine Karalis, Brookline, MA (US);

Antonio Varone, West Roxbury, MA (US);

Daniel Levner, Brookline, MA (US);

Riccardo Barrile, Boston, MA (US);

Assignee:

EMULATE, Inc., Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 31/00 (2006.01); C12M 1/12 (2006.01); C12M 3/06 (2006.01); C12N 5/09 (2010.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
C12M 23/16 (2013.01); C12M 25/02 (2013.01); C12N 5/0693 (2013.01); G01N 33/5011 (2013.01); G01N 33/5017 (2013.01);
Abstract

The invention generally relates to a microfluidic platforms or 'chips' for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.


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