The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2024
Filed:
Mar. 15, 2018
Modernatx, Inc., Cambridge, MA (US);
Oregon State University, Corvallis, OR (US);
Siddharth Patel, Corvallis, OR (US);
Emily Robinson, Corvallis, OR (US);
Anna Brown, Corvallis, OR (US);
Orn Almarsson, Cambridge, MA (US);
Kerry E. Benenato, Sudbury, MA (US);
Staci Sabnis, Cambridge, MA (US);
Gaurav Sahay, Portland, OR (US);
Ashwani Kumar Narayana, Portland, OR (US);
ModernaTX, Inc., Cambridge, MA (US);
Oregon State University, Corvallis, OR (US);
Abstract
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.