The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2024
Filed:
Nov. 07, 2019
The Catholic University of Korea Industry-academic Cooperation Foundation, Seoul, KR;
Mi-La Cho, Seoul, KR;
Dong-Yun Shin, Seoul, KR;
Jong-Young Choi, Seoul, KR;
Chul-Woo Yang, Seoul, KR;
Sung-Hwan Park, Seoul, KR;
Seon-Yeong Lee, Seoul, KR;
Min-Jung Park, Seoul, KR;
Joo-Yeon Jhun, Seoul, KR;
Se-Young Kim, Seoul, KR;
Hyeon-Beom Seo, Seoul, KR;
Jae-Yoon Ryu, Seoul, KR;
Keun-Hyung Cho, Seoul, KR;
Abstract
The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone. Thus, the present invention may be used in the field of pharmaceutics relating to transplantation rejection or various immune disorders possibly occurring after transplantation.