The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11965889 B1

Date of Patent:

Apr. 23, 2024

Filed:

Jan. 22, 2020

Lysine monomethylated derivative and corresponding antibody and use thereof

Applicant:

Pmt Biolabs Inc, Hangzhou, CN;

Inventor:

Zhongyi Cheng, Hangzhou, CN;

Assignee:

PMT BIOLABS INC, Hangzhou, CN;

Attorney:

Muncy, Geissler, Olds & Lowe, P.C.

Primary Examiner:

Shafiqul Haq

Int. Cl.

CPC ...

C07K 16/18 (2006.01); C07C 233/47 (2006.01); C07K 7/08 (2006.01); C07K 14/435 (2006.01); C07K 16/44 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01);

U.S. Cl.

CPC ...

G01N 33/6848 (2013.01); C07C 233/47 (2013.01); C07K 7/08 (2013.01); C07K 14/43504 (2013.01); C07K 16/18 (2013.01); C07K 16/44 (2013.01); G01N 33/53 (2013.01); C07K 2317/34 (2013.01); C07K 2317/92 (2013.01); G01N 2440/12 (2013.01);

Abstract

The present invention relates to artificially synthesized modified mono-methylated lysines and modified mono-methylated lysine derivatized polypeptides. The present invention also relates to production of a completely new antibody by using this modified mono-methylated lysine and modified mono-methylated lysine derivatized polypeptide as an antigen, this antibody can be used in recognizing and enriching the modified polypeptide after the lysine mono-methylated polypeptide being derivatized in vitro. By using this antibody, it is capable of detecting whether a mono-methylation modification is present in amino acids on the polypeptide sequence, the present invention also relates to a preparation method of said antibody. Moreover, the present invention also relates to a method for identifying and quantifying the lysine mono-methylated modified substrate in cell or tissue; more specifically, it belongs to identifying and quantifying the lysine mono-methylated modified substrate in cell or tissue by using proteomics approach of affinity enrichment for specific antibody and mass spectrometry.

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Cheng, Zhongyi. (2024). Lysine monomethylated derivative and corresponding antibody and use thereof (U.S. Patent No. 11965889). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11965889

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