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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11965160 B1

PDFFull Text
Date of Patent:
Apr. 23, 2024

Filed:

Jan. 11, 2021

Von willebrand factor (vwf)-targeting agents and methods of using the same

Applicants:

Duke University, Durham, NC (US);

Ohio State Innovation Foundation, Columbus, OH (US);

Inventors:

Shahid M. Nimjee, Columbus, OH (US);

Bruce Sullenger, Durham, NC (US);

George A. Pitoc, Durham, NC (US);

Juliana Layzer, Durham, NC (US);

Assignees:

Duke University, Durham, NC (US);

Ohio State Innovation Foundation, Columbus, OH (US);

Attorney:

Quarles & Brady, LLP

Primary Examiner:

Amy H Bowman

Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 31/7115 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); A61P 7/02 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 31/7115 (2013.01); A61K 45/06 (2013.01); A61K 47/554 (2017.08); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61P 7/02 (2018.01); C12N 15/115 (2013.01); C12N 2310/113 (2013.01); C12N 2310/16 (2013.01); C12N 2310/317 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/3515 (2013.01);
Abstract

Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.

Find Patent Forward Citations

Nimjee, Shahid. (2024). Von willebrand factor (vwf)-targeting agents and methods of using the same (U.S. Patent No. 11965160). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11965160

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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