The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Mar. 08, 2019
Cornell University, Ithaca, NY (US);
Tri-institutional Therapeutics Discovery Institute, New York, NY (US);
Timothy Hla, Wellesley, MA (US);
Irina Jilishitz, New York, NY (US);
Peter Meinke, Scotch Plains, NY (US);
Andrew Stamford, Chatham, NJ (US);
Michael Foley, New York, NY (US);
Ayumu Sato, Zushi, JP;
Yasufimi Wada, Fujisawa, JP;
Yoshiyuki Fukase, Edgewater, NJ (US);
Asato Kina, Fujisawa, JP;
Hiroki Takahagi, Fujisawa, JP;
Hideyuki Igawa, Edgewater, NJ (US);
William J. Polvino, Trinton Falls, NJ (US);
Cornell University, Ithaca, NY (US);
Tri-Institutional Therapeutics Discovery Institute, New York, NY (US);
Abstract
The various examples presented herein are directed to compounds of the formula A-L-Het-L-Cyor a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Hetis heterocyclyl containing at least two heteroatoms; Cyis a heterocyclyl; Lis a bond, alkyl, alkenyl or alkynyl linker; Lis an acyl or alkyl linker; and A and Cyare different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.