The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Jul. 20, 2022
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Yoshiaki Isshiki, Kamakura, JP;
Fumio Watanabe, Gotemba, JP;
Masaki Tomizawa, Kamakura, JP;
Kihito Hada, Kamakura, JP;
Kazuo Hattori, Gotemba, JP;
Kenichi Kawasaki, Kamakura, JP;
Ikumi Hyodo, Kamakura, JP;
Toshihiro Aoki, Kamakura, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X, X, Xand Xare each independently —CR═ or N═, Ris, for example, a halogen atom, Ris, for example, —S(═O)—NH—R, Ris, for example, a Calkyl group, Ris, for example, a hydrogen atom, Ris, for example, a halogen atom, Ris, for example, a hydrogen atom, and Ris, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.