The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Sep. 16, 2022
Applicants:
Massachusetts Institute of Technology, Cambridge, MA (US);
Universität Zürich, Zürich, CH;
Inventors:
Angela Nicole Koehler, Belmont, MA (US);
Shelby Doyle, Cambridge, MA (US);
Becky Leifer, Malden, MA (US);
Madeleine Henley, Brighton, MA (US);
Beat W. Schaefer, Zürich, CH;
Marco Wachtel, Zürich, CH;
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
Universität Zürich, Zürich, CH;
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08);
Abstract
The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.