The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Mar. 08, 2021
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The Scripps Research Institute, La Jolla, CA (US);
Trustees of Dartmouth College, Hanover, NH (US);
Barney Graham, Rockville, MD (US);
Jason Mclellan, Austin, TX (US);
Andrew Ward, La Jolla, CA (US);
Robert Kirchdoerfer, La Jolla, CA (US);
Christopher Cottrell, La Jolla, CA (US);
Michael Gordon Joyce, Washington, DC (US);
Masaru Kanekiyo, Chevy Chase, MD (US);
Nianshuang Wang, Austin, TX (US);
Jesper Pallesen, La Jolla, CA (US);
Hadi Yassine, Doha, QA;
Hannah Turner, La Jolla, CA (US);
Kizzmekia Corbett, Wheaton, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The Scripps Research Institute, La Jolla, CA (US);
Trustees of Dartmouth College, Hanover, NH (US);
Abstract
Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.