The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Jan. 18, 2017
Applicant:
Celgene Corporation, Summit, NJ (US);
Inventors:
Rajesh Chopra, Sutton, GB;
Anke Klippel, Westfield, NJ (US);
Assignee:
CELGENE CORPORATION, Summit, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A01K 67/0278 (2024.01); A61K 39/00 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A61K 39/001102 (2018.08); G01N 33/57484 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0331 (2013.01);
Abstract
Provided are transgenic mice whose genome comprises a nucleic acid sequence encoding human cereblon (CRBN) or a fragment thereof, wherein endogenous mouse CRBN is not expressed in the transgenic mice. Also provided are cells, cell lines, tissues, and organs derivable from the transgenic mice, and methods for producing and using such mice.