The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Apr. 17, 2018
Applicant:
The Jackson Laboratory, Bar Harbor, ME (US);
Inventors:
James Keck, Granite Bay, CA (US);
Chunting Ye, Roseville, CA (US);
Assignee:
The Jackson Laboratory, Bar Harbor, ME (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); A01K 67/0278 (2024.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6863 (2013.01); A01K 67/0278 (2013.01); C07K 16/2809 (2013.01); C07K 16/2818 (2013.01); C07K 16/2887 (2013.01); C07K 16/2893 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0325 (2013.01);
Abstract
Humanized mouse models and methods are provided for determining whether administration of an immunomodulatory drug likely elicits a severe cytokine release syndrome in a human. Humanized mouse models and methods are also provided for determining the immunotoxicity in a human of a drug candidate or of drug combinations.