The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Apr. 27, 2018
Ventana Medical Systems, Inc., Tucson, AZ (US);
Nelson Alexander, Marana, AZ (US);
Aoune Barhoumi, Tucson, AZ (US);
Melinda Day, Oro Valley, AZ (US);
Lisa Gallegos, Tucson, AZ (US);
Katherine Leith, Tucson, AZ (US);
Samantha Rajkovich, Marana, AZ (US);
Esteban Roberts, Tucson, AZ (US);
Stacey Stanislaw, Tucson, AZ (US);
Eric Walk, Tucson, AZ (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially 'personalized' anti-tumor vaccines or immune cell based therapies.