The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 16, 2024

Filed:

May. 03, 2018
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Victor Velculescu, Dayton, MD (US);

Jillian A. Phallen, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); C12Q 1/6806 (2018.01); G16B 20/20 (2019.01); G16B 25/10 (2019.01); G16B 30/10 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/6806 (2013.01); G16B 20/20 (2019.02); G16B 25/10 (2019.02); G16B 30/10 (2019.02); C12Q 2600/112 (2013.01); C12Q 2600/156 (2013.01);
Abstract

Provided herein are methods of detecting circulating tumor DNA, cancer cell mutations, and/or cancer cells harboring one or more cancer cell mutations. In some embodiments, methods provided herein include detecting one or more genetic alterations in cell-free DNA. In some embodiments, methods provided herein for detecting one or more genetic alterations in cell-free DNA can be performed when the subject is not known to harbor a cancer cell and/or a cancer cell mutation (e.g., when the subject is not known to harbor a cancer cell having the cancer cell mutation).


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