The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Nov. 09, 2017
Applicants:
Osaka University, Osaka, JP;
Kyoto University, Kyoto, JP;
Inventors:
Kiyotoshi Sekiguchi, Osaka, JP;
Fumi Ebisu, Osaka, JP;
Hidetoshi Sakurai, Kyoto, JP;
Mingming Zhao, Kyoto, JP;
Megumu Saito, Kyoto, JP;
Assignees:
OSAKA UNIVERSITY, Osaka, JP;
KYOTO UNIVERSITY, Kyoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0735 (2010.01); A61K 35/34 (2015.01); A61K 35/545 (2015.01); A61P 9/00 (2006.01); A61P 21/00 (2006.01); A61P 43/00 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01); C12N 5/10 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 35/34 (2013.01); A61K 35/545 (2013.01); A61P 9/00 (2018.01); A61P 21/00 (2018.01); A61P 43/00 (2018.01); C12N 5/0658 (2013.01); C12N 5/069 (2013.01); C12N 5/10 (2013.01); C12N 2501/115 (2013.01); C12N 2501/12 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/165 (2013.01); C12N 2501/91 (2013.01); C12N 2501/998 (2013.01); C12N 2506/45 (2013.01);
Abstract
Provided is a method for inducing pluripotent stem cells to differentiate into somatic cells in a culture medium containing a heparin binding growth factor, the method comprising bringing cells into contact with a conjugate of a laminin E8 fragment and a growth factor binding domain-containing fragment of a heparan sulfate proteoglycan. According to the present invention, pluripotent stem cells can be induced to differentiate into any desired somatic cells in a highly efficient manner.