The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
May. 02, 2023
Salk Institute for Biological Studies, La Jolla, CA (US);
Juan Carlos Izpisua Belmonte, La Jolla, CA (US);
Keiichiro Suzuki, La Jolla, CA (US);
Reyna Hernandez-Benitez, La Jolla, CA (US);
Jun Wu, Farmers Branch, TX (US);
Yuji Tsunekawa, Kobe, JP;
Salk Institute for Biological Studies, La Jolla, CA (US);
Abstract
Disclosed herein are homology-independent targeted integration methods of integrating an exogenous DNA sequence into a genome of a non-dividing cell and compositions for such methods. Methods herein comprise contacting the non-dividing cell with a composition comprising a targeting construct comprising the exogenous DNA sequence and a targeting sequence, a complementary strand oligonucleotide homologous to the targeting sequence, and a nuclease, thereby altering the genome of the non-dividing cell.