The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Mar. 14, 2018
Applicant:
Applied Stemcell, Inc., Milpitas, CA (US);
Inventors:
Ling-Jie Kong, Union City, CA (US);
Ruby Yanru Tsai, San Jose, CA (US);
Xiuling Chi, San Jose, CA (US);
Assignee:
APPLIED STEMCELL, INC., Milpitas, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/79 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01); C07H 21/02 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C12N 15/113 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 15/63 (2013.01); C12N 15/79 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); C12N 2310/20 (2017.05);
Abstract
The present disclosure provides compositions and methods for enhanced expression of exogenous genes in eukaryotic cells. The method involves introducing into a mammalian cell an exogenous nucleic acid. wherein the exogenous nucleic acid intearates into a locus of the genome that comprises an extended methylation-free CpG island. Also provided are chromosomal loci, sequences for enhanced and stable expression of exogenous genes.