The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Dec. 22, 2017
Applicant:
The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone, San Francisco, CA (US);
Inventors:
Yadong Huang, San Francisco, CA (US);
Yaisa Andrews-Zwilling, San Francisco, CA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/7088 (2006.01); A61K 35/30 (2015.01); A61K 38/17 (2006.01); A61P 25/28 (2006.01); C12N 5/0797 (2010.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7088 (2013.01); A61K 35/30 (2013.01); A61K 38/1716 (2013.01); C12N 5/0623 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron.