The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
Oct. 16, 2017
Children's Medical Center Corporation, Boston, MA (US);
Ospedale San Raffaele S.r.l., Milan, IT;
Politecnico Di Milano, Milan, IT;
Fondazione Telethon Ets, Rome, IT;
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Alessandra Biffi, Boston, MA (US);
Marco Peviani, Boston, MA (US);
Davide Moscatelli, Milan, IT;
Alessia Capotondo, Milan, IT;
Rita Milazzo, Milan, IT;
Umberto Capasso Palmiero, Milan, IT;
CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
OSPEDALE SAN RAFFAELE S.R.L., Milan, IT;
POLITECNICO DI MILANO, Milan, IT;
FONDAZIONE TELETHON ETS, Rome, IT;
DANA-FARBER CANCER INSTITUTE, INC, Boston, MA (US);
Abstract
The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.