The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2024
Filed:
May. 23, 2022
Applicant:
National Institute of Immunology, Delhi, IN;
Inventors:
Pushkar Sharma, Delhi, IN;
Monika Chauhan, Delhi, IN;
Assignee:
National Institute of Immunology, New Delhi, IN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 223/28 (2006.01); A61K 31/55 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/55 (2013.01); A61P 25/28 (2018.01);
Abstract
The present disclosure provides methods for treating Alzheimer's disease (AD) comprising administering clomipramine or a pharmaceutically acceptable salt thereof. The administration of clomipramine increases the levels of TAp73 and decreases the levels of proliferating cell nuclear antigen (PCNA) and cleaved caspase-3 in the AD patients. The methods of the present disclosure reduce the neurodegeneration and improve the cognitive and functional decline in AD patients.